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The GLP-1 receptor: a key target in glucose and appetite regulation The glucagon-like peptide-1 receptor (GLP-1R) is a GPCR found primarily in pancreatic -cells, brain, heart, kidney, and the gastrointestinal tract
Crucially, they act on appetite centres in the brain, particularly the hypothalamus, reducing hunger signals and food cravings
It is still important for patients taking GLP-1 medication to limit muscle wasting through exercise and high-quality protein. Losing muscle can lower metabolic rate and physical strength
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