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Lipid- and protein-rich tissues often require additional pre-treatment steps (e.g., fat removal, detergent/ethanol washing, alkaline saponification), which are necessary for matrix reduction but may alter particle surfaces, promote aggregation, or partially degrade polymers [6, 171]

Fluoxetine (Prozac), introduced in 1988, quickly became the company's best-selling product for treatment of depression, but Lilly lost its US patent protection for the product in 2001

From a clinical standpoint, there are three distinct stages in the progression of autoimmunity: Stage 1: At this stage, individuals have positive antibodies but do not experience any symptoms or have a diagnosed disease