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Treatment with berbamine, bergapten, and carveol significantly improved disorientation of the sciatic nerve and spinal cord

Once symptoms improve and kidney function stabilizes, the treatment can be restarted at a lower dose, with gradual increases as tolerated

However, tirzepatide has 14 unique amino acids (engineered from the GIP sequence) and an amidated exenatide-like C terminus as opposed to GLP-1 which allow the peptide to possess a GIPR binding ability equivalent to GIP(142) and to steadily interact with GLP-1R with a reduced potency compared to GLP-1 27 (Fig