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Before GLP-1s like Ozempic were approved, earlier trials tested a range of doses and found that lower doses produced some weight loss and blood sugar improvements

If your GIP receptors have desensitized alongside your GLP-1 receptors, switching to a pure GLP-1 agonist removes the GIP stimulus entirely, allowing those receptors to recover while you maintain GLP-1 mediated appetite suppression with a different agonist profile

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