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penetration-enhanced preparations (including palmitoylated versions such as Pal-GHK) are needed for meaningful dermal delivery Injectable advantages: bypasses the skin barrier entirely, delivers GHK-Cu systemically, and can be combined in the same protocol as BPC-157 and TB-500 for comprehensive wound care The distinction between topical and injectable GHK-Cu is clinically important and is not simply a matter of convenience

It is important to note that many of the studies that examined the efficacy of lipoic acid in the treatment of diabetic neuropathy have been primarily conducted by one German research group and funded by the manufacturer of lipoic acid in Germany (82)

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