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Epithalon upregulates telomerase activity and elongates telomeres, which has prompted research in areas including life extension, anti-aging, and the inhibition of tumorigenesis [2, 3]

Furthermore, Annexin V-FITC/PI double staining illustrated the mechanism of the cytotoxic properties of BV in T-47D and resistant cells through apoptosis, which was confirmed with increased expression of pro-apoptotic protein (BAX) and reduced levels of the anti-apoptotic (Bcl-2) protein, as shown immunohistochemically in vivo

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