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This usually requires the addition of an activating reagent such as dimethylaminopropanol (DMA) or tetrahydrofuran alcohol (THF)

Weight Loss Results: Head-to-Head Data Semaglutide Clinical Trial Results The STEP (Semaglutide Treatment Effect in People with Obesity) trial program is the most comprehensive dataset for any anti-obesity medication: STEP 1 (Wilding et al., 2021, NEJM ): 1,961 adults with obesity (BMI 30+) or overweight (BMI 27+) with comorbidities Semaglutide 2.4 mg weekly vs