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a , Dose-response curves showing relative cell number after 72 h of treatment of HCC-1806 cells with vincristine (0-5 nM) in the presence of the MRP1 inhibitor MK-571 (0-15 M) (n = 8 technical replicates from one experiment)

However, a recent study demonstrated the anticancer effects of retinol (Li et al., 2016)

Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways

3.2 Therapeutic potential via paracrine mechanisms The therapeutic effects of MSCs are primarily mediated through their paracrine activity, which involves the secretion of bioactive factorssuch as growth factors, chemokines, cytokines, and EVsto modulate the local microenvironment (Pittenger et al., 2019