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FIGURE 1 Upregulated ANGPTL4, DPP-4-integrinb1, lipid load, damaged mitochondria, and activated c-GAS-STING pathways led to higher inflammation and fibrogenesis in the diabetic kidney, whereas ANGPTL4 depletion demolished this fibrotic phenotype in the kidney during diabetes

P values lower than 0.05 were considered significant

doi: 10.3389/fnins.2023.1188839 Received 17 March 2023 Accepted 22 May 2023 Published 23 June 2023 Volume 17 - 2023 Edited by Hisashi Shirakawa, Kyoto University, Japan Reviewed by Jess Fernndez Abascal, Universidad Pablo de Olavide, Spain

However, the risk of getting Parkinsons disease increases with age and is considerably higher by the time an individual reaches the age of 85