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If oral ibuprofen is necessary , consider these risk-reduction strategies: Use the lowest effective dose (200-400 mg) for the shortest duration possible Take ibuprofen with or after food to minimise gastric irritation (ensuring this is at least 30 minutes after taking Rybelsus) Consider gastroprotection with a proton pump inhibitor (PPI) if you have risk factors for gastric complications, including: age 65, history of peptic ulcer or GI bleeding, concurrent use of anticoagulants, antiplatelets, SSRIs/SNRIs, or corticosteroids [13] [14] Avoid prolonged courses without medical supervision Do not take ibuprofen if you are dehydrated or experiencing vomiting or diarrhoea Alternative analgesics may include codeine-based preparations for more severe pain, though these can cause constipation and nausea, potentially compounding Rybelsus side effects

10.1017/s0033291720000951 151 SongY.CaoH.ZuoC.GuZ.HuangY.MiaoJ.et al (2023a)

Peptides 2018;100:4853

Because these processes can emerge earlier or be more pronounced in people with HIV, this community can help us identify interventions that may improve healthspan more broadly. In a related pilot study published in npj Aging last month, Corley and another team of researchers found that taking semaglutide for 24 weeks: Reduced the rate of biological aging for 42% of participants with HIV and metabolic dysfunction-associated steatotic liver disease (MASLD) also known as fatty liver disease as measured by the DunedinPACE epigenetic clock