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Description

They are typically released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and NLRPs (Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing, also known as NOD-like receptors)

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Ultimately, improving outcomes will demand a shift toward precision phenotyping, the integration of addiction medicine, and multicenter trial frameworks that reflect the real-world complexity of disease

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