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The benefit of GLP-1 RAs appears to be time-dependent: in the LEADER trial, for instance, the absolute risk reduction in all-cause death became more pronounced with longer follow-up, rising from 0.3% at 1 year to 1.4% at 3 years [40]

This research helps to rationally design the next-generation analgesics, and is expected to reduce the side effects of opioids without affecting their analgesic effect, or even enhance the analgesic effects.

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Severe abdominal pain , particularly if constant or progressively worsening, which could indicate pancreatitisa rare but serious adverse effect of GLP-1 medicines