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The ratio of fat-mass loss to lean-mass loss was similar to that reported in lifestyle-based intervention in the Look AHEAD trial (241) and surgical treatment for obesity (242)

The short answer: delayed stomach emptying from GLP-1 therapy may reduce oral contraceptive absorption, making backup contraception a practical consideration

These thresholds serve as the baseline for clinical decision-making: Obesity: Body Mass Index (BMI) 30 kg/m Overweight with Comorbidity: BMI 27 kg/m accompanied by at least one weight-related condition, such as: Hypertension Dyslipidemia Type 2 Diabetes (T2D) Obstructive Sleep Apnea (OSA) Insight: These thresholds are not merely entry requirements but indicators of metabolic risk

Cureus, 18(1), e101693