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Notwithstanding these limitations, disproportionality analysis still remains a crucial tool for detecting potential safety signals associated with drugs and guiding further investigations [Reference Chen, Ding, Fu and Xiao16, Reference Zhou, Peng, Lin, Jiang, Peng and Gu29, Reference Blau, Tella, Taylor and Rother33, Reference Ding, Chen, Yang, Fang, Cao and Liu52]

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The animals were housed at 35 mice per cage and treated in accordance with the Guide for the Care and Use of Laboratory Animals published by the National Academy of Sciences and the National Institutes of Health