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In a phase 3, double-blind, randomized, controlled trial, 2,539 adults with a body-mass index (BMI) of 30 or greater, or 27 or greater with at least one weight-related complication, were given weekly subcutaneous injections of tirzepatide (5 mg, 10 mg, or 15 mg) or a placebo for 72 weeks

Gastroparesis is a disorder in which the contractions of the stomach muscles weaken, making digestion and the passage of food to the intestines difficult

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Some patients experience constipation or loose stools following overeating episodes, as the sudden larger food volume disrupts the medication's effect on gut motility