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When your B12 levels are optimized, your metabolism functions more efficiently, which may help you burn calories more effectively even at rest
Improved health-related quality of life with tirzepatide versus semaglutide in adults with obesity or overweight from the SURMOUNT5 trial
Additionally, rapid weight loss mobilizes stored fat, and your body must process released metabolitesa metabolically demanding process that can temporarily deplete energy reserves
[15] [27] In October 2025, the FDA further expanded the indication for semaglutide (as Rybelsus) to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes who are at high risk for these events
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