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Future directions The results presented in this study suggest that targeting fundamental biological mechanisms holds promise for the future development of ASD therapies

Enhancing stem cell function via culturing under hypoxic condition, which is known to prime MSCs to reduce cellular ROS levels, improved chondrogenic differentiation of MSCs [20] and cartilage regeneration in both post-traumatic and focal early OA rabbit models [21]

Depending on the patient, monitoring may include: Weight trends Waist circumference Blood pressure Glucose and A1C Lipids Liver markers Kidney markers Thyroid markers when appropriate Nutrient markers when indicated Hormone considerations when relevant Adjust the Plan as the Body Changes A patients needs at the start of treatment may not be the same after losing 20, 40, or 60 pounds

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