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The group at risk of endometrial hyperplasia are those women using a GLP-1 and also using TD oestrogen (which will be unaffected by the GLP-1 agonist) and an oral progestogen, as the absorption of the progestogen may be reduced while the oestrogen stays the same, leaving the woman with an unbalanced regime and an insufficient amount of progestogen to protect her endometrium from the oestrogen