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253 Genetic variations that affect the synthesis or degradation of ECM components can alter the mechanical properties of the ACL, influencing its ability to withstand mechanical stress

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Moreover, it has been reported that in type 2 diabetic patients with adequate glycaemic control by metformin monotherapy, several markers of cardiovascular risk are improved by addition of liraglutide treatment, suggesting that metformin and liraglutide may have additive or even synergistic effects on vasculature 14

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