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They also inhibit movement of the 2 subunit from dorsal root ganglion neurons to central terminals in the dorsal horn, which disrupts the reuse of the 2 subunit from endosomal compartments

doi: 10.1097/00005344-199505000-00013

Toxicol Lett 1999;104:13742

Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]