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To view or add a comment, sign in Once-Weekly Semaglutide 7.2 mg Shows Superior Weight Reduction in Obesity: Results from the STEP UP Trial Today, results from the STEP UP phase 3b trial were published in The Lancet Diabetes & Endocrinology, evaluating a higher dose of once-weekly subcutaneous semaglutide (7.2 mg) in adults with obesity but without diabetes

Mouse-study observations In the Billon 2023 and Billon 2024 studies, mice dosed at 25-50 mg/kg IP for up to 28 days showed no overt toxicity, no sickness-related weight loss, no liver-enzyme signal at the doses tested, and no cardiac dysfunction