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A practical clinical framework for evaluating tirzepatide-related cognitive benefit in a given patient should assess four domains before initiating therapy and at 6 months: (1) baseline cognitive screen using the Montreal Cognitive Assessment (MoCA), (2) polysomnography or sleep apnea screening, (3) fasting insulin and HOMA-IR, and (4) cardiovascular risk score

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Most patients benefit from ongoing treatment combined with lifestyle changes for lasting results