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In people with type 2 diabetes, GLP-1 secretion is blunted and beta-cell sensitivity to GIP is diminished, making pharmacological dual-receptor stimulation therapeutically meaningful [2]

Allergenic reaction may also be exaggerated

Studies demonstrate that many patients achieve significant improvement in binge eating with CBT-ED, with benefits often maintained at long-term follow-up

However, we assume that cost-effectiveness evaluations may vary from one population to another and according to the disease burden, and such findings may differ for the population for whom a combination of GLP-1RAs and SGLT2is is suitable