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Eli Lilly s (NYSE:LLY | LLY Price Prediction) GLP-1 therapy Zepbound has become the biggest weight loss drug since its introduction, outpacing Novo Nordisk s (NYSE:NVO) Wegovy in both sales momentum and patient preference

Preclinical data indicates that boosting cGAS-STING signaling while inhibiting autophagy might be a promising treatment option to improve patients outcomes

The larger benefit with the additional agonism of GIPr seems to be its effect on weight loss

Aim for 30-40 grams of protein per meal to preserve muscle mass during rapid weight loss, pair carbohydrates with fiber to stabilize blood sugar despite delayed gastric emptying, and include omega-3 fats for satiety and micronutrient absorption