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Instead, it is used as a part of a more comprehensive hormone replacement therapy plan

25G Safety in Pregnancy and Breastfeeding There have been no investigations into the use of berberine in pregnancy and lactation to date

Moreover, in another study, L-theanine effectively regulated the secretion of cytokines such as IFN-, IL-2, IL-4, IL-10, IL-12, and TNF- except for IL-6 by activating the mRNA and protein expression of Ras-related protein Rap-1A (Rap1A), 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), and farnesyl diphosphate synthase (FDPs) in the mevalonate synthesis pathway of rat splenic lymphocytes (93)

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