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Curr Opin Food Sci

Amylin analogues like cagrilintide act directly on amylin receptors in the brainstem , producing satiety through the area postrema

Design and Development of Nrf2 Modulators for Cancer Chemoprevention and Therapy: A Review

GLP-1 boosts insulin secretion from pancreatic beta cells in a glucose-dependent manner (meaning it only works when blood glucose is elevated, reducing hypoglycemia risk), suppresses glucagon secretion from pancreatic alpha cells (reducing glucose production by the liver), slows gastric emptying (prolonging satiety and reducing postprandial glucose spikes), and starts GLP-1 receptors in the brain (very the hypothalamus) to reduce appetite and food intake