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Indications and Usage for Zoloft ZOLOFT is a selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of (1): Major depressive disorder (MDD) Obsessive-compulsive disorder (OCD) Panic disorder (PD) Posttraumatic stress disorder (PTSD) Social anxiety disorder (SAD) Premenstrual dysphoric disorder (PMDD) Zoloft Dosage and Administration If inadequate response to starting dosage, titrate in 25-50 mg per day increments once weekly in MDD, OCD, PD, PTSD, and SAD (2.1) See Full Prescribing Information for titration in PMDD (2.2) Hepatic impairment: o Mild: Recommended starting and maximum dosage is half recommended dosage (2.4) o Moderate or severe: Not recommended (2.4) When discontinuing ZOLOFT, reduce dose gradually (2.6, 5.4) Oral solution: Must be diluted before administration (2.7) Contraindications Warnings and Precautions Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents, but also when taken alone

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Disclosures Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study

Skipping doses or significantly delaying them allows medication levels to drop below therapeutic thresholds, potentially reducing effectiveness and triggering increased appetite or cravings