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What they found: Visible skin pigmentation in all subjects after 5 to 7 injections Pigmentation was strongest in exposed areas (face, neck, hands), suggesting synergy with low UV exposure Nausea in 90 % of subjects in initial doses, gradually subsiding Spontaneous erections in all male subjects , an unexpected finding Loss of appetite with average weight loss of 1.2 kg over 10 days Mild increase in blood pressure in the first hour after injection Why it matters: This was the first published clinical study of Melanotan II in humans