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12 Canonical GLP-1 receptor signaling involves coupling GLP-1R with Gs, a subtype of G subunit, but GLP-1R can also initiate diverse signaling patterns through non-Gs pathways

Some studies have shown that differences in the expression of GLP-1R on the surface of different pancreatic cells may affact the development of pancreatic cancer

A large number of studies have shown that the longer the disease lasts for, the more other serious diseases will develop such as liver cancer and liver failure