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Introduction Glucagon-like peptide-1 (GLP-1) is an incretin mainly secreted by intestinal L cells ( Circadian rhythms are endogenous biological rhythms with a cycle of approximately 24 hours in organisms, mainly regulated in response to light and darkness changes, and are formed by various transcription factors and promoters that form an autoregulatory feedback loop ( This review focus on GLP-1 and its secretion rhythm as a clue to explore the factors influencing GLP-1 secretion rhythm and the role of exogenous GLP-1-like regulation in GLP-1 rhythm