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Incidence of SJS and TEN is estimated to be 1.06.0 per million and 0.41.2 per million, respectively

This hypothesis suggests that by identifying deregulated metabolic pathways, new diagnostic targets can be identified, allowing for the implementation of optimized treatments, including during fetal life, with the aim of providing protective effects for the brain development of individuals with T21 (Fayal Guedj, Bianchi, and Delabar 2014)

Ritenbaugh, C

Its pathogenesis is thought to involve various factors, including insulin resistance, lipotoxicity, gut/nutrient-derived signals, adipocytokines, oxidative stress, and genetic factors