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A 2025 study published in JMIR Formative Research found that active subscribers on Second Natures GLP-1-supported programme lost an average of 19.1% of their body weight at 12 months, with 77.7% achieving at least 10% weight loss

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PA could alleviate alcohol-induced hepatic steatosis in zebrafish larvae by regulating alcohol and lipid metabolism, which was closely related to the regulation of the AMPK-acetyl-CoA carboxylase (ACC) signaling pathway (Liu et al., 2021)