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Blood levels of GPX are lower in patients with T2D compared to healthy controls and the decrement in GPX activity was more severe in T2D patients with obesity compared to T2D patients without obesity [58]

[DOI] [PubMed] [Google Scholar] SHEFFNER A

3 Thyroidbrain axis pathophysiology and neurological manifestations The major mechanistic routes linking thyroid dysfunction to neuropsychiatric manifestations are summarized in Figure 2, highlighting disrupted hormone transport/activation in the brain, neurotransmitter imbalance, oxidative stressneuroinflammation, and bloodbrain barrier vulnerability

The role of ethnography affects the research on the epistemological and methodological levels since it will ground the research in the middle of things by proposing to exceed an a priori definition of Social Innovation