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JAMA Network Open (August 12, 2025) reports higher risk of nonarteritic anterior ischemic optic neuropathy across ~1.5M patients, and a separate analysis in ~185k found a modest uptick in diabetic retinopathywhile sight-threatening events were less frequent on GLP-1s

Ipamorelin Side Effects Available clinical trials on ipamorelin do not report any side effects other than nausea and other mild gastrointestinal issues