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The most evidence-backed options include: Glucomannan reduces appetite by expanding in the stomach before meals Berberine improves insulin sensitivity and regulates blood sugar Green Tea Extract (EGCG) mildly increases calorie burn through thermogenesis Whey Protein preserves lean muscle during a calorie deficit Magnesium corrects a deficiency linked to impaired metabolism Psyllium Husk supports gut health and reduces post-meal blood sugar spikes These supplements work best as one part of a medically supervised weight loss plan, not as standalone solutions

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In addition, the competition is intensified by ongoing innovations in drug formulations, such as combination therapies, that provide patients with more comprehensive treatment options

Ther Adv Med Oncol 9(8):551-564, 2017