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The protein stability and activity of ATPase sarcoplasmic/endoplasmic reticulum Ca 2+ transporting 2 (SERCA2) were enhanced by lnc -EDCH1 through interaction, which helps maintain Ca 2+ homeostasis and activates the protein kinase AMP-activated catalytic subunit alpha 1 (AMPK) pathway, thereby improving mitochondrial efficiency and activating the slow-twitch myofiber phenotype [81]

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