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In the vascular system, catechol estrogens regulate nitric oxide production and have other modulatory functions ( 3 Estrogen signaling in skin Estrogen actions are mediated through canonical nuclear and/or non-canonical membrane-initiated steroid signaling ( ++ , cAMP, or protein kinase cascades) that regulate downstream transcription and epigenetic factors (Figure 3), although this has not been directly investigated, and data regarding the role and expression of ER in skin cells and during wound healing are inconsistent (Verdier-Sevrain et al., 2004)

doi: 10.1016/j.intimp.2007.12.007

A 2018 review identified several demonstrated capabilities of GHK-Cu: Research from 2015 noted that GHK-Cu may stimulate collagen production, regulate the skin remodeling process, attract immune cells to injury sites, and restore replicative vitality to fibroblasts (cells that help form connective tissue) in patients whove undergone radiation therapy for cancer

In contrast, rhGH had no significant effect on these cardiac parameters