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PLoS ONE 11 , e0158408 (2016)

Starting from a low dose, it escalates based on patient response and tolerance

It is worth stating plainly that this lean subgroup is exactly where the read-across from obesity, diabetes, and MASLD data is weakest: those trials enrolled few, if any, participants resembling a normal-weight woman with androgen-driven, intrinsic insulin resistance, so the confidence interval around any predicted effect in her is wide and honestly unknowable from the current evidence

Circulation 138(13):13301342 Jansweijer JA, Nieuwhof K, Russo F, Hoorntje ET, Jongbloed JD, Lekanne Deprez RH, Postma AV, Bronk M, van Rijsingen IA, de Haij S, Biagini E, van Haelst PL, van Wijngaarden J, van den Berg MP, Wilde AA, Mannens MM, de Boer RA, van Spaendonck-Zwarts KY, van Tintelen JP, Pinto YM (2017) Truncating titin mutations are associated with a mild and treatable form of dilated cardiomyopathy