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Genome-wide analyses reveal thousands of differentially methylated sites affecting steroid hormone signaling and inflammation pathways ( Histone modifiers are also dysregulated: histone deacetylases (HDAC1-3, SIRT1), methyltransferases (EZH2, MLL1), and demethylases (LSD1) alter chromatin states, contributing to progesterone resistance, inflammation, and fibrosis

meanwhile, cardiomyocyte as an important source of energy, if its mitochondrial function deteriorates, it would lead to myocardial I/R injury

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