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Nrf2 signalling changes can be due to increased Nrf2 degradation, blockage of its nuclear translocation, changes in post-transcriptional modifications, and an increase in specific regulatory miRNAs [142]

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Finally, prebiotics, such as 3% galacto-oligosaccharide/fructo-oligosaccharide, have been shown to prevent valproic acid-induced ASD-associated social and cognitive deficits by suppressing microglial activation, lowering Th1 and Th17 and increasing Treg populations, improving intestinal barrier function, and normalizing the gut microbiota composition and SCFA pool [369]