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During the in vivo investigation on AR mice, it has been confirmed that treatment with (2 S , 7 S )- O -(2-methyl butanol)-columbianetin reduced the histamine, IgE, and IL-1 levels in serum also reduced the MIP-2 and Intercellular Adhesion Molecule 1 (ICAM-1) protein levels and eosinophils and mast cells in the nasal mucosa tissue and reduced the spleen weight and increased the IFN- levels in the spleen tissue ( S , 7 S )- O -(2-methyl butanol)-columbianetin is a potent anti-AR compound that acts via inhibition of the MAPK/NFB signaling pathway, inhibition of proinflammatory and Th2 cytokines, and increasing the Th1 cytokines

includes whole grains, lean meat, poultry, fish and nuts

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