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Hypermobility Spectrum Disorders The hypermobility spectrum disorders (HSD) are diagnosed based on: Medical history Physical examination Ruling out other conditions that can cause similar symptoms EDS and HSD Diagnosis in Children Hypermobility Spectrum Disorders Children and adolescents from age 5 through biological maturity can be assessed for HSD using the 2023 Diagnostic Framework for Pediatric Joint Hypermobility

By contrast, synapsin-Cre enables more neuron-selective Gipr deletion