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These invasive gut surgical procedures, aimed to reduce absorptive surface area of the proximal GI tract, such as Roux-en-Y gastric by-pass (RYGB) or Sleeve Gastrectomy (SLG), are associated with an improved glycaemic control, weight loss, and often with complete remission from T2DM ( Despite this, the complete remittance of a great fraction of RYGB patients represents a fascinating new case-series that points at the importance of the EECs and its modulation of the whole-body metabolism ( A panoply of contradictory studies have attempted to establish what is the possible role of GLP-1 or other gut peptides in the rapid, and long-lasting remittance from T2D after bariatric surgery, but no consensus about the identity of the molecular players has yet been reached (39)

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But while two medical doctors who examined the research call the results reassuring, they say that neither study fully answers the question of whether these drugs are safe in those with preexisting mental health problems. In the first study, researchers from the Perelman School of Medicine at the University of Pennsylvania analyzed data from more than 3,300 people who participated in one of four semaglutide clinical trials and who did not have a major mental health condition

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