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Do not inject the medication until you have thoroughly evaluated its appearance and consulted appropriate resources

Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha

A useful next step will be to integrate behavioural, physiological, and neuroimaging data so that clinically meaningful response subtypes and their predictors can be identified more reliably, with potential relevance for more individualised treatment planning

These policy options are intended to be bipartisan in nature and politically feasible