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Women of childbearing age using these medications must maintain reliable contraception and stop treatment immediately if pregnancy is planned or confirmed

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MITF regulates MC differentiation by controlling the expression of pigmentation genes (e.g., Tyr , Trp1 , and Trp2 ) and maintains cellular homeostasis by modulating genes involved, among others, in cell cycle progression (e.g., Cdk2 ) and apoptosis (e.g., Bcl2 ) (Goding and Arnheiter, 2019

We also found elevated levels of chemokine CXCL1 in females compared to males (main effect of sex: F (1,45) = 5.495, p 2 = 0.109, p = 0.024