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& Shalet, S.M

Consistent with this concept, butyrate has been shown to hinder epithelial inflammatory programs via the HDAC-NF-B axis while simultaneously reinforcing the integrity of tight junction proteins, thereby supporting a mechanistic framework in which SCFAs sufficiency couple anti-inflammatory signaling with barrier repair 163

Lai S, Petramala L, Muscaritoli M, Cianci R, Mazzaferro S, Mitterhofer AP, Pasquali M, DAmbrosio V, Carta M, Ansuini M, Ramaccini C (2020) -Lipoic acid in patients with autosomal dominant polycystic kidney disease

Furthermore, the gender distribution was relatively balanced, with 43.04% of the patients being male and 49.14% female, indicating no statistically significant difference (refer to Supplementary Tables S10,S11 for further details)