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Clinical evidence suggests that reducing food intake is more effective for weight loss than attempting to accelerate fat metabolism directly

Careful monitoring of blood pressure is recommended when initiating therapy in hypertensive patients, and those with baseline low blood pressure should use B-containing injections cautiously

Due to their cost, however, coverage of GLP-1s for obesity treatment in Medicaid, ACA Marketplace plans, and most large employer firms remains limited, and GLP-1 coverage in Medicare for treatment of obesity is prohibited under current law

Patients with a history of thrombocytopenia or any other hematologic disorder should also avoid using this formulation