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This results in higher levels of free, biologically active androgens, which can: Increase sebum production by sebaceous glands Promote follicular hyperkeratinisation (abnormal skin cell turnover) Contribute to the inflammatory processes underlying acne lesions When GLP-1 medications facilitate significant weight loss and improve insulin sensitivity, these hormonal disturbances may partially normalise

Globally, RNA sequencing of these SGBS adipocytes under starvation conditions yielded p53 knock down-mediated de-enrichment in p53, apoptosis, and inflammatory response pathways (Supplementary Fig

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Lower mitochondrial NAD+ means lower ATP output, which shows up as fatigue, reduced physical performance, and slower recovery from exercise