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CARDIOVASCULAR EFFECTS OF GLP-1 RAs IN HUMAN STUDIES Blood pressure and heart rate Circulating biomarkers and lipid profiles Carotid intima-media thickness LV function and reperfusion injury in patients with coronary artery disease Retrospective studies on cardiovascular outcomes A prospective randomized clinical trial with primary cardiovascular outcome: the ELIXA study Preclinical and preliminary clinical evidence has consistently revealed potential cardiovascular benefits from the administration of GLP-1 RAs

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Using both SGLT-2 and DPP-4 inhibitors as active comparators strengthened study validity, while register linkage minimized selection and recall bias by ensuring exposures were recorded independently of outcomes

New EASD-ADA consensus guidelines on managing hyperglycaemia in type 2 diabetes launched at EASD meeting