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Serious Adverse Events Seizures: There have been reports of increased seizure frequency in patients with a pre-existing seizure disorder

It is a small molecule that works by inhibiting the activity of an enzyme called nicotinamide N-methyltransferase (NNMT)

The 15-amino-acid sequence they eventually settled on (GEPPPGKPADDAGLV) is published and public

"The long- and short-term impact of elevated body mass index on the risk of new atrial fibrillation the WHS (women's health study)." J Am Coll Cardiol 55 (2010): 2319-2327